
New imaging technologies, such as multi-slice computed tomography, photon-emission computed tomography, and magnetic resonance imaging, might add value to conventional echocardiography in diagnosis and management of IE. Integrating clinical results, imaging, and biomarkers are traditionally applied in suspected IE modified Duke criteria. Early clinical suspicion and rapid diagnosis are crucial for adequate treatment and reduction of complications and mortality. The clinical manifestations of IE are protean and can involve all organic system.

The cardiac manifestations could include valvular vegetation, abscess, periannular extension of infection. Infection typically involves the cardiac valves (native or prosthetic) or an indwelling cardiac device.

It is a disease of the endocardial surface of the heart. Infective endocarditis (IE) was first described more than 350 years ago.
